文章摘要
张利,应荣敏,陈国达,黄一,单晓杭.钛合金磨粒流加工表面细胞黏附研究[J].高技术通讯(中文),2022,32(8):875~880
钛合金磨粒流加工表面细胞黏附研究
Research of surface cell adhesion on titanium alloy by abrasive flow machining
  
DOI:10.3772/j.issn.1002-0470.2022.08.010
中文关键词: 细胞黏附; 表面粗糙度; 钛合金; 磨粒流加工
英文关键词: cell adhesion, surface roughness, titanium alloy, abrasive flow machining
基金项目:
作者单位
张利 (浙江工业大学机械工程学院杭州 310032) 
应荣敏 (浙江工业大学机械工程学院杭州 310032) 
陈国达 (浙江工业大学机械工程学院杭州 310032) 
黄一 (浙江工业大学机械工程学院杭州 310032) 
单晓杭 (浙江工业大学机械工程学院杭州 310032) 
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中文摘要:
      采用磨粒流冲蚀方法加工钛合金薄片表面,所用磨粒粒径为8~18μm,得到具有不同表面粗糙度Ra值的钛合金薄片表面,在此基础上进行小鼠成骨细胞(MC3T3-E1)体外黏附实验,探究不同粗糙度Ra值对薄片表面细胞黏附性能的影响。实验结果表明,磨粒流加工处理后,钛合金薄片表面均匀性好,得到的表面粗糙度Ra范围为0.05~0.15μm,且发现钛合金对成骨细胞的黏附存在抑制作用,实验范围内Ra为0.08~0.10μm的薄片黏附率最高,其黏附效果最好。上述研究结果为磨粒流加工技术及钛合金表面生物相容性的后续研究奠定了基础。
英文摘要:
      The abrasive flow erosion method with abrasive particle size of 8-18μm is used to treat the surface of the titanium alloy sheet. The surface roughness with different Ra values is obtained. To explore the effects of different surface roughness Ra on the adhesion properties of cells on the sheet surface, the mouse osteoblasts (MC3T3-E1) adhesion experiments are conducted on the obtained sheets. The results show that after the abrasive flow processing,the surface uniformity of the titanium alloy sheet is good, and the surface roughness Ra is in the range of 0.05-0.15μm. Moreover, it is found that titanium alloy is not conducive to cell adhesion. Within experimental range, the titanium alloy sheets with surface roughness Ra ranges of 0.08-0.10μm have the highest adhesion rate, which means it provides a better condition for the osteoblasts to adhere to. These results lay a foundation for further research on abrasive flow processing technology and the surface biocompatibility of titanium alloys.
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