| Yan Hanbing (闫寒冰)* **,Zhang Xu*,Liu Ming*,Yuan Fang*,Wang Sikai* **,Chen Hongda*.[J].高技术通讯(英文),2020,26(1):79~84 |
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| A 16-channel high-voltage reconfigurable and flexible-controlled implantable wireless closed-loop system for SCI repair |
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| DOI：doi：10.3772/j.issn.1006-6748.2020.01.010 |
| 中文关键词: |
| 英文关键词: spinal cord injury (SCI) repair, implantable medical device, multi-electrode array, reconfigurable system, functional electrical stimulation |
| 基金项目: |
| Author Name | Affiliation | | Yan Hanbing (闫寒冰)* ** | (*State Key Laboratory on Integrated Optoelectronics, Institute of Semiconductors,
Chinese Academy of Sciences, Beijing 100083, P.R.China)
(**University of Chinese Academy of Sciences, Beijing 100049, P.R.China) | | Zhang Xu* | (*State Key Laboratory on Integrated Optoelectronics, Institute of Semiconductors,
Chinese Academy of Sciences, Beijing 100083, P.R.China) | | Liu Ming* | (*State Key Laboratory on Integrated Optoelectronics, Institute of Semiconductors,
Chinese Academy of Sciences, Beijing 100083, P.R.China) | | Yuan Fang* | (*State Key Laboratory on Integrated Optoelectronics, Institute of Semiconductors,
Chinese Academy of Sciences, Beijing 100083, P.R.China) | | Wang Sikai* ** | (*State Key Laboratory on Integrated Optoelectronics, Institute of Semiconductors,
Chinese Academy of Sciences, Beijing 100083, P.R.China)
(**University of Chinese Academy of Sciences, Beijing 100049, P.R.China) | | Chen Hongda* | (*State Key Laboratory on Integrated Optoelectronics, Institute of Semiconductors,
Chinese Academy of Sciences, Beijing 100083, P.R.China) |
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| 中文摘要: |
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| 英文摘要: |
| An adaptive closed-loop system for spinal cord injury (SCI) repair is designed. It integrates stimulation and recording on 16 pairs of electrodes. Two switches (SAS3T16/SAS1T16X2) fabricated in high-voltage 0.8μm process with online re-configurable function are proposed. These two switches are combined with commercial off-the-shelf (COTS) electronics to implement the closed-loop implantable system in compact module. The system includes amplifier for recording neural signals, high-voltage stimulator, power transmission device, central processing module and flexible implantable electrodes. Two customized switches route any electrode to amplifier or stimulator, and nerve stimulation and signal recording are performed through lead wire-driven channels. The entire system is able to operate at up to 28V, and is a biocompatible package with a volume of 42mm×35mm×8mm. This system solves several problems encountered in implantable devices: low flexibility, negative influence of stimulus artifacts on neural detection and low integration of electrodes. |
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